快速眼动睡眠期行为障碍的核素显像研究进展

摘要

快速眼动睡眠期行为障碍(RBD)是一种以快速眼动睡眠期肌张力迟缓现象消失,并出现与梦境相关的复杂运动为特征的发作性疾病.诸多研究表明特发性RBD是神经变性疾病(尤其是α-突触核蛋白病)的前驱期表现,RBD的结构和功能影像已成为目前的研究热点,包括经颅超声成像(TCS)、MRI、SPECT、PET等.在探求帕金森病等疾病早期诊断的生物学标志物的研究方法中,RBD核素显像是最有前景的方法之一,该文对此进行综述.%Rapid eye movement sleep behavior disorder (RBD) is a condition characterized by rap id eye movement sleep without atonia and with complex behaviors associated with dreams.Numerous studies have revealed that idiopathic RBD is the prodromal manifestation of neurodegenerative disorders,especially those mediated by α-synuclein.The structural and functional imaging of RBD,including transcranial sonog raphy (TCS),MRI,SPECT,PET,are increasingly becoming the hot issues.This review summarizes the radionuclide imaging in RBD,which may be one of the most promising modalities to detect the biomarkers for early diagnosis of neurodegenerative disorders.