注射用艾司奥美拉唑钠对大鼠胃酸分泌作用的影响

摘要

目的:为获得国产注射用艾司奥美拉唑钠 (艾速平(R)) 对大鼠胃酸分泌的药效学数据,比较其与原研药 (耐信(R)) 在动物体内抑酸效果的差异.方法:本研究选取SD大鼠93只,随机分成6组:艾速平低剂量组 (10 mg·kg-1·d-1)、艾速平高剂量组 (50 mg·kg-1·d-1)、耐信低剂量组 (10 mg·kg-1·d-1)、耐信高剂量组 (50 mg·kg-1·d-1)、生理盐水组和空白组.于d 5和d 14,检测大鼠胃内p H值、胃蛋白酶及胃泌素蛋白表达水平.结果:国产注射用艾司奥美拉唑钠对比原研用药d 5及d 14后,均可有效抑制大鼠胃酸分泌,两组大鼠胃内p H值水平、胃蛋白酶及胃泌素表达水平均一致,无统计学差异.结论:国产注射用艾司奥美拉唑钠可有效抑制大鼠胃酸分泌,具有强而持久的抑酸效果.%Objective: To compare the effects of generic (Aisuping()) and original intravenous esomeprazole (Nexiumumumumum()) on gasctric acid secretion. Methods: Ninety-three SD rats were randomly divided into six groups, including Aisuping() Low-dose group ( 10 mg·kg-1·d-1), Aisuping high-dose() Group ( 50 mg·kg-1·d-1), Nexium() Low-dose group ( 10 mg·kg-1·d-1), Nexium() High-dose group ( 50 mg·kg-1·d-1), saline group and blank group.Then, the secretion levels of gastric acid, pepsin and gastrin were detected on day 5 and day 14 after the multiple dose administration. Results: There was no significant difference in the secretion levels of gastric acid, pepsin and gastrin between Aisuping() And Nexium() Groups on day 5 and day 14. Both Aisuping() And Nexium() Could effectively inhibit gastric acid secretion in rats. Conclusion: Generic esomeprazole for injection has long and persistent gastric acid inhibitory effect in rats, which is equivalent to original esomeprazole.