Objective: To investigate the characteristics of adverse drug reaction (ADR) in children caused by L-asparaginase (L-ASP) from clinical practice, and to provide reference for rational use of drugs. Methods: Two cases of pediatric asthma induced by multiple doses of L-ASP were reported. Literature about L-ASP-in-duced ADR reported in domestic pharmaceutical journals from 1979 to 2011 was collected and analyzed statistically. Safety issues of L-ASP in children were further considered based on its structure, administration routes, dosing interval, and action mechanisms. Results: ADR caused by L-ASP in children was common. The main type was allergic reaction, and followed by digestive system damage and blood abnormalities. A small number of children had acute hemorrhagic necrotizing pancreatitis and severe ADR in nervous system, which had poor prognosis. Conclusion : More attention should be paid to children to avoid and reduce the occurrence of ADR induced by L-ASP.%目的:以临床实例出发探讨左旋门冬酰胺酶不良反应在儿童的发生特点,为临床用药安全提供依据.方法:报道反复使用左旋门冬酰胺酶致儿童过敏性哮喘2例,并检索1979-2011年国内医药期刊公开报道的左旋门冬酰胺酶致不良反应的病例,从药物结构、给药方式、给药时间间隔以及药物作用机制等方面进一步论述左旋门冬酰胺酶在儿童用药的安全性问题.结果:左旋门冬酰胺酶不良反应较常见,其不良反应以过敏反应为主,其次为消化系统损害和血液系统异常,且少数急性出血坏死性胰腺炎、重度神经系统不良反应患儿预后极差.结论:临床应重视左旋门冬酰胺酶的用药安全问题,积极采取措施防范不良反应的发生.
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