Caspase抑制剂F1013血浆蛋白结合率的测定

摘要

目的:测定新Caspase抑制剂F1013的血浆蛋白结合率.方法:采用超滤法和高效液相色谱法测定F1013的血浆蛋白结合率.结果:F1013与Wistar大鼠血浆和正常人血浆的蛋白结合率分别为(49.19±10.84)％和(51.96±1O.OO)％.结论:F1013与血浆蛋白具有中等强度的结合.%Objective: To determine plasma protein binding of the novel caspase inhibitor F1013. Methods: The ultrafiltration was employed to determine the human plasma protein binding of F1013. The plasma concentrations of F1013 were measured by HPLC. Results: The protein binding rates were (49. 19 ±10. 84)% and (51.96 ± 10. 00)% in rat and human plasma. Conclusion: The plasma protein binding of F1013 has a moderate intensity.