小分子肿瘤血管阻断剂对肿瘤外血管的影响

摘要

小分子肿瘤血管阻断剂虽然可以选择性地破坏恶性肿瘤已形成的新生血管,从而达到治疗癌症的目的,但在临床试验中发现其有肿瘤外血管的不良反应.本文通过回顾小分子肿瘤血管阻断剂的临床前研究,总结分析该类药物对肿瘤外血管的作用影响,警示临床中可能发生的药物不良反应.%The small molecule vascular targeting anticancer drugs are currently in the phase of clinical research.In clinical trials,patients were found to have different side effects,so it reminds us that we still have the questions about safety and tolerability of the drug.Through analyzing toxicity reactions of small molecule vascular targeting agents in the existing non-clinical trials,we summarized and evaluated their effects on normal tissues and organs.