Tumor Angiogenesis and Lymphangiogenesis Effects on Size-Regulated Profiles of Tumor-derived Molecular Dissemination to Draining Lymph Node-resident Immune Cells

摘要

Our results indicate that both VEGF-C overexpression and VEGF receptor 2 inhibition partially restore dendritic cell trafficking to TDLN. Furthermore, VEGF receptor 2 inhibition but not VEGF-C overexpression recovers the accumulation of lymph-transported tumor-derived macromolecules within cell subpopulations resident within distinct localities in TDLN in a hydrodynamic size-regulated manner. Our findings have important implications in the role of tumor lymphatic transport in the immunological crosstalk between tumors and their draining LN, as well as in the development of drug delivery strategies to mitigate its deleterious effects.