3％高渗盐水联合利巴韦林雾化治疗上呼吸道感染的疗效观察

摘要

目的：观察3％高渗盐水联合利巴韦林超声雾化吸入治疗上呼吸道感染的疗效。方法将163例上呼吸道感染患者随机分为三组（A组57例、B组53例和C组53例）。在常规治疗的基础上，A组加用0．9％生理盐水10 ml＋庆大霉素8万U＋地塞米松5 mg超声雾化吸入；B组加用0．9％生理盐水10 ml＋利巴韦林0．1 g＋地塞米松5 mg超声雾化吸入；C组加用3％高渗盐水10 ml＋利巴韦林0．1 g＋地塞米松5 mg超声雾化吸入，2次／d，疗程4 d。比较三组疗效和咽痛、咽痒、声嘶及咳嗽缓解时间及不良反应。结果 C组在咽痛、咽痒、声嘶及咳嗽缓解时间上优于A组；在咽痒方面优于B组。 A组有1例用庆大霉素雾化后出现哮喘等过敏反应，另两组未出现不良反应。结论3％高渗盐水联合利巴韦林超声雾化吸入治疗上呼吸道感染能改善症状，缩短病程，无不良反应。%Objective To observe the effects of 3% hypertonic saline combined with ribavirin atomization inhalation in the treatment of upper respiratory tract infection.Methods 163 patients with upper respiratory tract in-fection were randomly divided into three groups, with 57 cases in group A, 53 cases in group B and 53 cases in group C.On basis of the conventional treatment in the three groups, Group A was treated with ultrasonic atomization inhala-tion of 0.9%saline 10 ml+Gentamicin 80 000 units+5 mg dexamethasone;Group B was treated with ultrasonic at-omization inhalation of 3%hypertonic saline 10 ml+ribavirin 0.1 g+5 mg dexamethasone; Group C was with 3%hypertonic saline 10 ml+ribavirin 0.1 g+5 mg dexamethasone ultrasonic atomizing inhalation on the basis of the conventional treatment, all of the three groups were treated two times a day, four days for a course of treatment.The efficacy and sore throat, itchy throat, hoarseness and cough relief time and adverse reaction were compared among the three groups.Results Sore throat, itchy throat, hoarseness and cough relief were improved better in group C than those in group A.Pharyngeal itching relieving time was shorter in group C than that in group B.No adverse reactions occurred except that one case in group A experienced asthmatic symptoms after using gentamicin aerosol because of allergic reaction.Conclusion 3%hypertonic saline combined with ribavirin ultrasound atomization inhalation is ef-fective and safe in the treatment of upper respiratory tract infection.It can improve clinical symptoms and shorten the course of disease.