8－OHdG 与 p－EGFR 在舌鳞癌中的表达及两者的相关性

摘要

Objective To detect the expressions of 8-hydroxydeoxyguanine(8-OhdG) and phospho-epithelial growth factor receptor ( p-EGFR) in tongue squamous cell carcinoma ( TSCC) and their correlation .Methods The ex-pressions of 8-OHdG and p-EGFR in 30 specimens of tongue squamous cell carcinoma tissues and adjacent -carcinoma tissues were detected by immunohistochemistry .The correlation between 8-OHdG expression and p-EGFR expression was analyzed by Spearman rank correlation analysis .Results Both 8-OHdG and p-EGFR were highly expressed in the TSCC tissues, and their positive rates were 80.0%, 56.7%respectively, whereas the low expressions which were shown with positive rate of 16.7%, 6.7% respectively , were observed in the adjacent-carcinoma tissues .The ex-pressions of 8-OHdG and p-EGFR in carcinoma tissue were significantly higher than those in the adjacent-carcinoma tissue(P<0.05), and the statistically significant correlation was observed between 8-OHdG expression and p-EGFR expression ( P<0.05 ) .Conclusion Reactive oxygen species express in oral cancer , which is positively correlated to p-EGFR.%目的探讨舌鳞状细胞癌组织中活性氧的标志物8－羟基脱氧鸟苷（8－OHdG ）和磷酸化表皮生长因子受体（ p－EGFR）的表达水平，并分析二者的相互关系。方法应用免疫组化法检测30例舌鳞癌组织及其癌旁组织中8－OHdG和p－EGFR表达，通过相关性分析探讨两者之间的关系。结果8－OHdG和p－EGFR在舌癌组织中高表达，阳性表达率分别为80．0％、56．7％；两者在癌旁组织中呈低表达，阳性表达率分别为16．7％、6．7％，它们在癌组织中的阳性表达率均显著高于癌旁组织（ P＜0．05），8－OHdG的表达与p－EGFR的表达具有显著相关性（ P＜0．05）。结论该研究初步确定活性氧在口腔癌中的表达和作用，以及其与磷酸化EGFR的正相关性。