Objective To investigate the value of cerebral blood source of nerve neurotrophic factor ( BD-NF) , homocysteine ( Hcy) and somatostatin ( SS) combined with monitoring in the diagnosis post-stroke vascular de-mentia(VD).Methods Thirty patients with VD after stroke were selected as VD group , 30 patients with cerebral apoplexy ( non vascular dementia ) as stroke group and 30 healthy people as the control group .The risk factors and re-lated history of the VD group and the stroke group were analyzed , and the differences of Hcy , SS and BDNF were compared among the three groups and the levels of SS , Hcy and BDNF were compared among the three subgroups of the VD group with different levels of severity of VD .Results ( 1 ) There was significant difference in the history of hypertension between the VD group and the stroke group (P<0.05);(2)The levels of serum BDNF and SS in the VD group were lower than those in the stroke group and the control group ( P<0.01 );serum level of Hcy in the VD group was significantly higher than that in the stroke group and the control group ( P<0.01 );( 3 ) The levels of serum BD-NF, Hcy and SS among different levels of severity in VD patients were significant different (P<0.01).Conclusion The levels of serum SS , Hcy and BDNF are beneficial to the early diagnosis and assessment of the severity of vascular dementia .%目的：探讨血脑源性神经营养因子（BDNF）、同型半胱氨酸（Hcy）和生长抑素（SS）联合监测在脑卒中后血管性痴呆（ VD）中的诊断价值。方法选取30例脑卒中后血管性痴呆患者为VD组、30例脑卒中（非血管性痴呆）患者为脑卒中组和30名健康体检者为对照组。分析VD组、脑卒中组的危险因素及相关病史，比较三组间血BDNF、Hcy和SS水平差异，不同严重程度VD患者血BDNF、Hcy和SS水平差异。结果（1）VD组、脑卒中组高血压病史比较，差异有统计学意义（P＜0.05）；（2）VD组血BDNF、SS水平低于脑卒中组、对照组（ P＜0.01）；VD组血Hcy水平明显高于脑卒中组和对照组（ P＜0.01）；（3）不同严重程度VD患者血BDNF、Hcy和SS水平比较，差异有统计学意义（ P＜0.01）。结论动态观察VD患者血BDNF、Hcy和SS水平，有利于血管性痴呆的早期诊断和评估病情严重程度。
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