Objective To investigate the treatment of Butylphthalide Soft Capsules in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods Sixty-four patients with DEACMP were randomly divided into two groups:patients in the control group (n = 32 )were treated with routine drugs combined with hyperbaric oxygen therapy;patients in observation group (n=32)were treated with Butylphthalide Soft Capsules in addition to the same methods as the control group. We compared MMSE score distribution,the changes of Barthel index (BI)of activities of daily living (ADL)scale,abnormal rate of electroencephalogram (EGG)in the two groups before treatment and at the third month after treatment. Results MMSE score distribution:after treatment,the observation group had more patients in the 27-30 and 21-26 score ranges than the control group (P <0.05). After treatment,the activities of daily living of the two groups were significantly improved,and the BI index of the observation group was significantly higher than that of the control group (t=7.6617,P <0.01). The abnormal rate of EGG in the observation group was lower than that in the control group (59.3% vs .87.5%,χ2 = 4.267,P < 0.05 ). The total effective rate of the observation group was significantly higher than that of the control group (96.9% vs .78.1%,P < 0.05 ). Conclusions Butylphthalide Soft Capsules combined with conventional DEACMP treatments can effectively improve the patient's cognitive function and quality of life,reduce EGG abnormities,and improve the therapeutic effect.%目的 探讨丁苯酞软胶囊治疗一氧化碳中毒迟发性脑病患者的临床疗效.方法 将64例一氧化碳中毒迟发性脑病患者随机将其分成对照组和丁苯酞治疗组,每组各32例.对照组给予常规药物联合高压氧治疗,丁苯酞治疗组在常规药物联合高压氧治疗的基础上联合丁苯酞软胶囊治疗.治疗后3个月观察两组患者的简易精神智能量表(MMSE)评分、日常生活活动能力(ADL)量表的Barthel指数(BI)和脑电图(EGG)异常率的变化,并对患者总体疗效进行评价.结果 MMSE评分比较:丁苯酞治疗组患者经治疗后其MMSE评分在>26分、20~26分的比例高于对照组(P<0.05).治疗后两组患者的日常生活能力均明显得到改善,且丁苯酞治疗组治疗后BI指数高于对照组(t=7.6617,P<0.01),EGG异常率较对照组低(59.3%比87.5%;χ2=4.267,P>0.05),总有效率明显高于对照组(96.9%比78.1%,P<0.05).结论 在一氧化碳中毒迟发性脑病常规治疗基础上联合丁苯酞软胶囊治疗能够有效改善患者的认知功能及生活质量,减少EGG的异常,提高疗效.
展开▼
