强迫症与精神分裂症错误相关负电位的比较研究

摘要

Objective To study error-related negativity (ERN) abnormalities in palienls with obsessive-compulsive disorder (OCD) or wilh schizophrenia (SZ). Methods Twenty-one OCD palienls, 19 first episode schizophrenia patienls and 23 heallhy controls were recruiled in the presenl sludy. Both ERN and correcl-relaled negalivily ( CRN) were analyzed. Results ERN amplitude was significantly increased in OCD palienls (Z =-2.60, ρ＜0. 01) while significantly decreased in schizophrenia patients ( Z = - 2. 16, ρ＜ 0. 05 ) , as compared to health controls. ERN peak latency was longer in schizophrenia than in the conlrol groups (ι = 3. 60, P < 0. 01). Compare d with OCD patients, schizophrenia patients showed a significantly decreased ERN amplitude ( Z = -3. 75 , ρ＜0. 01) and a prolonged ERN latency ( ι = 2. 70, ρ＜0. 05 ) . There were not differences in eilher CRN amplitude or CRN latency among those three groups (ρ＞0. 05 ) . The correlation between ERN/CRN and clinical symptoms was not significant either among OCD groups or among schizophrenia groups (ρ＞0. 05 ) . Conclusions OCD and schizophrenia patients have different ERN abnormatities, suggesting the po-tential value of ERN in clinical differential diagnosis of OCD and schizophrenia.%目的 比较强迫症和精神分裂症患者的错误相关负电位(error-related negativity,ERN).方法 检测21例强迫症患者和19例首发精神分裂症患者的ERN和正确相关负电位(correct-related negativity,CRN),并与23名正常对照进行比较.结果与正常对照组相比,强迫症组ERN波幅增高(Z=-2.60,P＜0.01),精神分裂症组ERN波幅降低(Z=-2.16,P＜0.05)而潜伏期延长(t=3.60,P＜0.01).与强迫症组相比,精神分裂症组的ERN波幅降低(Z=-3.75,P＜0.01)而ERN潜伏期延长(t=2.70,P＜0.05).CRN波幅和潜伏期在三组间差异无统计学意义(P>0.05).无论是强迫症组,还是精神分裂症组,其ERN/CRN指标与临床精神症状之间均未见相关(P>0.05).结论 强迫症和精神分裂症的ERN均存在异常但方向相反,提示ERN可能作为二者鉴别诊断的参考.