抑郁症、焦虑症与强迫症患者Stroop效应及事件相关电位的比较研究

摘要

目的:探讨色词Stroop测验及事件相关电位P300检测在抑郁症、焦虑症、强迫症患者认知功能的差异及评估价值.方法:对123例抑郁症、121例焦虑症、68例强迫症患者及110名健康志愿者(正常对照组)进行色词Stroop测验及Brain Master脑诱发电位系统完成视觉P300检测.结果:病例组较正常对照组、抑郁症组较焦虑症组和强迫症组Stroop测验D卡片的应用时间明显延长、正确阅读数减少(F=7.011,F=20.94;P均<0.05).抑郁症组P300的N1、P2、N2潜伏期短于焦虑症组及强迫症组,P3波幅低于焦虑症组及强迫症组(P均<0.05);焦虑症组P2潜伏期及P3、P2波幅低于强迫症组(P均<0.05).结论:抑郁症、焦虑症及强迫症患者均存在不同程度的认知功能损害,抑郁症损害程度较重.%Objective:To investigate the characteristic of Stroop color-word association test(CWT)and event-related potential P300 in patients with depression disorder (DD ),anxiety disorder (AD )and obsessive compulsive disorder(OCD),and to explore the assessment value of the CWT and P300 test for the recognition function of the patients. Method:A total of 123 patients with depression,121 patients with anxiety and 68 patients with obsessive compulsive disorder and 110 normal controls were enrolled in the study. The CWT and e-vent-related potential P300 by Brain Master instrument were conducted. Results:Compared with control group,patient groups had longer application time and less accurate reading in D part of CWT(P<0. 05). DD group showed longer application time and less accurate reading in D part of CWT than AD and OCD group(P<0. 05). Compared with AD,OCD group,DD group had shortened latency of N1,P2,N2 and shortened amplitudes of target P3(P<0. 05);Compared with OCD group,AD group had shortened latency of P2 and shortened ampli-tudes of target P3,P2(P<0. 05). Conclusion:DD,AD,OCD patients all have cognitive dysfunction,but DD patients are more apparent.