儿童青少年精神分裂症患者眶额脑回沟区结构模式

摘要

Objective To explore the association between the structural patterns of orbitofrontal sulcogyral pattern (OSP)and the susceptibility to schizophrenia in children and adolescents patients with schizophrenia. Methods Seventy-two childhood and adolescence schizophrenia aged 6~18 years were enrolled as the case group and 78 sex-, age-, education-matched healthy children served as the control group. MR images were acquired with a 3.0 T Magnetom Symphony MRI system. Positive and Negative Syndrome Scale (PANSS) was used to evaluate the symptom severity of patients.The pattern type of OFC was classified based on continuity among medial (MOS),lateral (LOS)and transverse (TOS) orbital sulci according to the method of Chiavaras and Petrides'. The orbitofrontal cortex (OFC) sulcogyral pattern was classified into three types(TypeⅠ,TypeⅡ,TypeⅢ)in each hemisphere. Results There were significant differences in the distribution of OFC patterns between the control and the case group (Left hemisphere: Χ2=6.668,P=0.036; Right hemisphere: Χ2=7.501,P=0.024). The linear regression analysis showed that Type Ⅲ in either hemisphere was associated with more severe symptoms in schizophrenia patients (B=7.214, P=0.008). Conclusions Type Ⅲ sulcogyral pattern may be a morphological risk marker for schizophrenia. Compared to the other two types, the Type Ⅲ expression is associated with more severe clinical symptoms.%目的 探讨儿童青少年精神分裂症患者眶额脑回沟区结构模式(orbitofrontal sulcogyral pattern, OSP)与精神分裂症易感性及症状的关联. 方法 纳入72例儿童青少年精神分裂症患者和78名健康儿童青少年对照,均对头部进行3.0T核磁共振扫描,分别根据左右半脑内眶沟和侧眶沟之间的连接模式将受试者OSP分为Ⅰ型、Ⅱ型、Ⅲ型3种类型,并采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评估患者症状.结果 与对照组相比,患者组中双侧大脑半球Ⅲ型 OSP 的构成比均较高(左半脑 Χ2=6.668, P=0.036;右半脑Χ2=7.501,P=0.024).线性回归分析示,左或右半脑为Ⅲ型OSP是PANSS评分较高的预测因素(B=7.214,P=0.008).结论 Ⅲ型OSP可能是精神分裂症易感性的形态学标志,且可能与精神分裂症症状严重程度相关.