目的 观察硝酸舍他康唑乳膏治疗儿童皮肤念珠菌病的疗效和安全性.方法 将就诊的100例皮肤念珠菌病患儿分为两组,治疗组50例,外搽硝酸舍他康唑乳膏2次/d,对照组50例,外搽硝酸咪康唑软膏2次/d,疗程7～14d.观察其临床疗效和不良反应.结果 治疗组临床痊愈率92.00％,对照组64.00％,两组比较差异有统计学意义(P＜O.01).与对照组比较,治疗组起效更快、皮疹消失时间更短(P＜0.01).不良反应少而轻.结论 硝酸舍他康唑乳膏治疗儿童皮肤念珠菌病起效快,安全有效,具有较高的临床应用价值.%Objective To evaluate clinical efficacy and safety of sertaconazole nitrate cream in the treatment of children's skin candidiasis (moniliasis). Methods One hundred patients were enrolled in the test and were divided into 2 groups. Sertaconazole nitrate cream was applied topically to the affected areas of the body twice daily for 14 days in the treatment group. Miconazole nitrate ointment was applied topically to the affected areas of the body twice daily for 14 days in the control group. The efficacy and the adverse reaction were observed. Result Treatment groups curative rate is 92. 00% and control group's 64. 00% ( P < 0. 01). Compared with the control group, the treatment group produced the effect more quickly with a shorter cured period ( P <0. 01). There was little adverse effect observed in the test. Conclusion Sertaconazole nitrate cream acts effectively and safely on children's skin candidiasis. It is worthy of application.
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