复方盐酸特比萘芬凝胶抗皮肤癣菌感染的组织病理学疗效观察

摘要

Objective To assess the anti-inflammatory and anti-fungal efficacy of compound terbinafine hydrochloride gel as a topical antifungal drug for common dermatophytosis by pathological methods.Methods Guinea pig skin was infected by Trichophyton mentagrophytes to establish animal model.Treated them with four topical preparations and then investigated the recovery of their affected skin,comparing the therapeutic effect of compound terbinafine hydrochloride gel with other three formulations.Results In terms of curing guinea pig skin infected by Trichophyton mentagrophytes,compound terbinafine hydrochloride gel was more effective than terbinafine hydrochloride gel (P ＜ 0.05),triamcinolone acetonide,econazole nitrate cream (P＜0.01) and mometasone furoate gel (P＜0.01).Conclusions Compound terbinafine hydrochloride gel had better effect in the treatment and relapse prevention of guinea pig skin infection of Trichophyton mentagrophytes.%目的 通过病理学研究评估外用抗真菌药-复方盐酸特比萘芬凝胶对常见皮肤癣菌的抗炎和抗真菌疗效.方法 采用须癣毛癣菌感染豚鼠皮肤,建立动物模型,用4种皮肤外用制剂治疗,通过考察豚鼠病变皮肤的恢复情况,比较复方盐酸特比萘芬凝胶的治疗效果.结果 在治疗须癣毛癣菌感染豚鼠的皮肤真菌病方面,复方盐酸特比萘芬凝胶的疗效优于盐酸特比萘芬凝胶(P＜0.05)、曲安奈德益康唑乳膏(P＜0.01)和糠酸莫米松凝胶(P＜0.01).结论 复方盐酸特比萘芬凝胶对豚鼠皮肤须癣毛癣菌感染的治疗和预防复发效果较好.