Objective To observe and assessment of the efficacy and safety of luliconazole cream (1%) in patients with tinea cruris.Method Sixty patients positive for fungal elements on direct microscopy were equally and randomly divided into 2 groups:experimental group applying luliconazole cream (1%) once daily for 2 weeks,control group applying terbinafine cream (1%) once daily for 2 weeks.Efficacy was assessed on week 1,2,4,8 after initiation of treatment.Result 60 patients were eligible for the efficacy analysis.On week 1 after initiation of treatment,the clinical effective rate in the experimental group and control group was 40 % VS 23.3 %,the fungal clearance rate was 23.3% VS 20%.On week 2 after initiation of treatment,the clinical effective rate in the experimental group and control group was 80 % VS 70%,the fungal clearance rate was 70 % VS 63.3 %.On week 6 after the end of treatment,the clinical effective rate in the experimental group and control group was 83.3 % VS 70 %,the fungal clearance rate was 80 % VS 66.7 %.Conclusion Luliconazole cream (1%) have strong ability in relieving signs and symptoms of patients and low recurrence rate.Luliconazole cream (1%) is effective and well tolerated in the treatment of tinea cruris.%目的 观察和评价1%卢立康唑乳膏治疗股癣的疗效和安全性.方法 采用随机、双盲的原则将60例真菌镜检阳性的患者分为两组,治疗组外用1%卢立康唑乳膏,每天1次;对照组外用1%特比萘芬乳膏,每天1次.用药疗程均为2周.在开始用药后第1、2、4、8周评价临床和真菌学疗效.结果 60例患者均进入疗效分析.用药1周时,治疗组及对照组临床有效率分别为40%和23.3%,真菌清除率为23.3%和20%,用药2周时,治疗组及对照组临床有效率分别为80%和70%,真菌清除率为70%和63.3%,停药后6周,治疗组及对照组临床有效率分别为83.3%和70%,真菌清除率为80%和66.7%.结论 1%卢立康唑乳膏外用治疗股癣能迅速改善症状,复发率低,是安全有效的外用药物.
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