益生菌在防治老年人抗生素相关性腹泻中的应用与思考

摘要

Probiotics are living microbes which may give health benefit to the host. Despite their wide usage, the clinical use of probiotics lacks support from reasonable big data. Dozens of clinical studies have reported that probiotics are a promising strategy for the prevention and treatment of antibiotic-associated diarrhea (AAD). However, based on data from recent randomized controlled trials, it is hard to give a positive answer to whether probiotics could decrease the incidence of AAD in the elderly. Up till now, probiotics have a very good safety record. The use of probiotics may be beneficial for certain elderly patients including AAD, while needs be considered individually.%益生菌是一类能使其宿主获益的活体微生物，应用广泛，但目前并没有大数据支持其临床应用。很多临床研究证实了不同益生菌防治抗生素相关性腹泻（AAD）的有效性，但基于近年的数据，回答益生菌是否可降低老年人AAD发生率的科学依据尚显薄弱。总的来说，益生菌有着非常好的安全记录，特定人群包括AAD患者使用益生菌将会获益，但需要个体化。