CC趋化因子7研究进展

摘要

CC趋化因子7(CCL7)广泛表达于单核细胞、T淋巴细胞、树突状细胞等免疫细胞中.起初多作为炎性因子研究,但随着研究的深入,人们发现CCL7在免疫调节、组织损伤修复、与肝素结合、促纤维化等方面均发挥重要作用.因此,了解CCL7对于研究疾病的分子机制及治疗均有重要意义.随着多功能干细胞临床应用的进展,CCL7作为可诱导其迁徙的重要因子可能会提高细胞治疗的效率和疗效.本文将对CCL7的结构和作用进行综述.%Chemokine C-C motif ligand 7 (CCL7) is widely expressed in mononuclear cells, T lymphocytes, dendritic cells and other immune cells.CCL7 was regarded as inflammatory factor at first, but with further studies, evidence shows that it may play significant roles in immune regulation, tissue regeneration, interaction with heparin sulfate, and promoting fibrosis.Therefore, it is of great significance to investigate the functions of CCL7 in the molecular mechanisms and treatment of disease.With the progresses of the multipotent stem cells and progenitor cells in clinical practice, CCL7, as an important factor to induce their differentiation, may has the potential to enhance the efficiency and therapeutic benefits of cell therapy.This article reviewed the structure and functions of this chemokine.