慢性炎症是衰老和衰老相关疾病的一个主要发病风险因素，而胰岛素抵抗也在衰老过程中发挥作用。慢性炎症通过损害正常的脂质分布、脂肪组织功能、线粒体功能以及内质网应激引起胰岛素抵抗。脂肪组织的异常分布又可引起慢性炎症，慢性炎症进一步加剧胰岛素抵抗，慢性炎症和胰岛素抵抗相互作用可加速衰老过程。然而，一些研究表明，胰岛素抵抗本身也增加慢性炎症的作用。其中胰岛素依赖Akt信号传导通路的活性特别重要，因为它在胰岛素敏感器官如肝脏和肌肉中分布减少，并在非代谢器官如肾和主动脉中分布增加，原因可能是胰岛素抵抗和高胰岛素血症。%Chronic inflammation is a major risk factor for aging and senescence-related diseases , and insulin resistance also plays a role in the process of aging .Chronic inflammation impairs lipid accumulation , adipose tissue function , mitochondrial function , and causes endoplasmic reticulum (ER) stress, and all of these lead to insulin resistance .However, evidence shows that abnormal distri-bution of adipose tissue also causes chronic inflammation , while chronic inflammation further aggravates insulin resistance .Their interactions accelerates the aging process .However , some studies indicate that insulin resistance itself amplifies chronic inflammation . The activity of the insulin-dependent Akt signaling pathway is of importance due to its decrease in insulin -sensitive organs , like the liver and muscle , and its increase in non-metabolic organs , such as the kidneys and aorta ,which may underlie insulin resistance and hyperinsulinemia .
展开▼
