Objective To evaluate the clinical effect of composite salvia miltiorrhiza injection combined with isosorbide dinitrate in the treatment of coronary heart disease and angina pectoris. Methods Selected 80 patients with angina pectoris and randomly divided them into treatment group and control group, 40 cases in each group. The treatment group was given 20 ml intravenous injection, while giving 10 mg isosorbide dinitrate, 3 times a day by sublingua;control group was given isodose of isosorbide dinitrate alone. Observed the effect of drug and its impact on the quality of patients’life, after 28 days of drug administration. Results The total efficiency of study group and control group were 95%and 72.5%, respectively. There wer statistical differences between the two groups(P<0.01). After treatment, patients were sent weekly angina about (2.8±0.4)week/time and (4.9±0.6)week/time, and with the duration of (2.4±0.3)min/time and (4.6±0.4)min/time, respectively. The weekly dosage of nitroglycerin were (4.9±1.8)tablet/week and (8.5±1.6)tablet/week, differences were statistically significant(P<0.05). There were statistically significant differences between two groups in quality of patients’life scores before and after treatment(P<0.05). Conclusion Composite salvia miltiorrhiza injection combined with isosorbide dinitrate is effective in the treatment of angina pectoris.%目的：评价复方丹参注射液结合消心痛治疗冠心病心绞痛的疗效。方法收集冠心病心绞痛患者80例,随机分为治疗组40例和对照组40例,其中治疗组给予复方丹参注射液20 ml静脉注射,同时给予消心痛10 mg/次,3次/d舌下含服；对照组只给予等剂量消心痛；给药28 d后观察药物疗效及对患者生活质量的影响。结果治疗组和对照组总有效率分别为95.0%和72.5%,组间比较,差异具有统计学意义(P<0.01),两组患者治疗后心绞痛发作次数分别为(2.8±0.4)次/周和(4.9±0.6)次/周,心绞痛持续时间分别为(2.4±0.3)min/次和(4.6±0.4)min/次；硝酸甘油用量分别为(4.9±1.8)片/周和(8.5±1.6)片/周,组间比较,差异具有统计学意义(P<0.05)；两组患者生活质量评分治疗前后和治疗后组间比较,差异具有统计学意义(P<0.05)。结论复方丹参注射液结合消心痛在冠心病心绞痛治疗方面疗效确切。
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