血清TNF-α、IL-6、IL-8、IL-10在儿童肺炎支原体肺炎中的应用价值

摘要

目的：对血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和白细胞介素-10(IL-10)浓度在儿童肺炎支原体肺炎(MPP)中的应用价值进行探讨。方法90例肺炎支原体肺炎患儿作为肺炎组，其中轻症组50例，重症组40例；100例健康体检儿童作为对照组，对比肺炎组与对照组血清TNF-α、IL-6、IL-8和IL-10指标及轻症组与重症组血清中的各因子浓度。结果对照组与肺炎组治疗前血清中TNF-α、IL-6、IL-8和IL-10浓度差异具有统计学意义(P0.05)， TNF-α、IL-6及IL-8浓度均显著低于重症组，差异具有统计学意义(P0.05). They had much lower TNF-α, IL-6, IL-8 than the severe group, and their differences had statistical significance (P<0.05).Conclusion Serum TNF-α, IL-6, IL-8, IL-10 have certain correlation with mycoplasma pneumoniae pneumonia, and they are closely correlated with MPP degree. They can be used as evaluation indexes for clinical diagnosis, treatment and prognosis.