Expression and significance of TNF-α, IL-6, and IL-10 in the serum in patients with mycoplasma pneumonia

摘要

Objective:To explore the expression and clinical significance of TNF-α, IL-6, and IL-10 in the serum in patients with mycoplasma pneumonia (MPP).Methods:A total of 120 patients with MPP who were admitted in our hospital from August, 2014 to June, 2015 were included in the study and served as the observation group, while 60 healthy children who came for physical examinations were served as the control group. The serum levels of IL-6, IL-10, and TNF-α in the observation group at the acute phase and recovery phase were detected and compared with the control group. The serum levels of IL-6, IL-10, and TNF-α in mild and severe MPP patients were compared. The levels of IL-6, IL-10, and TNF-α in the serum and pleural fluid in MPP patients with or with no fibrosis change were compared and analyzed. Results:When compared with the control group, the serum TNF-α and IL-6 levels in the observation group at the acute phase and recovery phase were significantly elevated, while IL-10 level was significantly reduced. The serum TNF-α and IL-6 levels in MPP patients at the acute phase were significantly lower than those at the recovery phase, while IL-10 level was significantly higher than that at the recovery phase. The serum TNF-α and IL-6 levels in the severe group were significantly higher than those in the mild group, while IL-10 level was significantly lower than that in the mild group. TNF-α level in the pleural fluid in MPP patients with fibrosis change was significantly higher than that in MPP patients with no fibrosis change, while the comparison of IL-6 and IL-10 was not statistically significant. TNF-α level in MPP patients with fibrosis change in the pleural fluid was significantly higher than that in the serum, while the comparison of IL-6 and IL-10 was not statistically significant. IL-6, IL-10, and TNF-α levels in MPP patients with no fibrosis change in the pleural fluid were not statistically different from those in the serum.Conclusions:TNF-α, IL-6, and IL-10 are involved in the pathogenesis of MPP and are associated with the severity degree and treatment outcome, which can provide an important reference evidence for the clinical diagnosis, estimation, and treatment of MPP.