新型抗心梗药物果糖二磷酸镁的安全性研究

摘要

目的探讨新型抗心肌缺血药--果糖二磷酸镁(FDP-Mg)的安全性.方法采用Bliss法和QUANTAL程序测定和计算了FDP-Mg的LD50和95%可信限并对其过敏性、溶血性和血管刺激性进行研究.结果 FDP-Mg小鼠静脉注射的LD50为284.81mg/kg,95%可使限为267.42～302.20mg/kg;FDP-Mg大鼠静脉注射的LD50为335.15mg/kg,95%可信限为315.75～354.55mg/kg;FDP-Mg大鼠静脉滴注[1 000mg/(kg·h)]的MLD为(2 509.9±226.8)mg/kg.FDP-Mg不引起全身过敏反应和溶血现象,对血管也无刺激性.结论 FDP-Mg用于静脉给药安全可靠.%OBJECTIVE To test security of magnesium fructose-1,6-diphosphate (FDP-Mg), a novel drug of anti-myocardial ischemia. METHOD Bliss method(QUANTAL procedure)was used to calculate LD50 and 95% confident limit. Allergic, hemolytic and irritant tests of blood vessel were done.RESULTS LD50 of FDP-Mg for mice through intravenous injection was 284.81mg/kg and 95% confident limit was 267.42～302.20mg/kg, LD50 of FDP-Mg for rats through iv was 335.15mg/kg and 95% confident limit was 315.75～354.55mg/kg and MLD of FDP-Mg for rats through intravenous drip by [1 000mg/(kg·h)] was (2 509.9±226.8)mg/kg. FDP-Mg did not induce general allergic reaction and hemolysis, the irritant test of blood vessel was negative. CONCLUSION It is safe to administrate FDP-Mg by intravenous drip.