Objective To evaluate the short-term safety and efficacy of transurethral plasma kinetic enucleation of the prostate (PKEP)for benign prostatic hyperplasia (BPH)larger than 60 ml. Methods A retrospective analysis was carried out on clinical data and treatment outcomes of 87 cases of BPH with prostate volume larger than 60 ml in Fuzhou General Hospital of Nanjing Military Command from September 2013 to August 2015.The patients were divided into either PKEP group (45 cases)or plasma kinetic resection of prostate (PKRP)group (42 cases).The operation time,resected adenoma weight,decline in hemoglobin 1 day after operation,and catheterization and irrigation duration were recorded and analyzed.The international prostate symptom score (IPSS), quality of life score (QOL),post-void residual urine volume (PVR),maximum urinary flow rate (Qmax)before surgery and 1 ,3,6 months after operation respectively were evaluated. Results As compared with the PKRP group,the PKEP group excelled in greater resected prostate weight [(52.4 ±15.2)g vs.(40.0 ±14.1 )g,t =3.94,P =0.00],less decline in hemoglobin [(9 ±4)g /L vs. (17 ±6)g /L,t =-7.36,P =0.00],shorter irrigation duration [(1 .1 ±0.3)d vs.(1.4 ±0.5)d,t =-3.42,P =0.00],and shorter catheterization duration [(3.3 ±0.5)d vs.(5.5 ±0.5 )d,t =-20.50,P =0.00].There were no significant differences between the two groups in terms of operation time and operative complications such as transient incontinence and hematuria (P >0.05).Postoperative improvements in IPSS,QOL,PVR,and Qmax were similar between the two groups (P >0.05)but significantly improved as compared with before operation (P <0.05). Conclusion PKEP is a new,safe,and effective minimal invasive surgical option for the treatment of BPH larger than 60 ml.%目的：探讨经尿道双极等离子前列腺剜除术（plasma kinetic enucleation of the prostate，PKEP）治疗体积＞60 ml良性前列腺增生（benign prostatic hyperplasia，BPH）的近期疗效。方法回顾性分析2013年9月～2015年8月南京军区福州总医院泌尿外科治疗87例体积＞60 ml 的 BPH 患者的临床资料与手术治疗效果，其中 PKEP 组45例，经尿道等离子前列腺切除术（plasma kinetic resection of prostate，PKRP）组42例。比较2组手术时间、切除前列腺组织量、术后第1天血红蛋白下降值、膀胱冲洗时间、导尿管留置时间，术前及术后1、3、6个月国际前列腺症状评分（IPSS）、生活质量评分（QOL）、残余尿量（PVR）、最大尿流率（Qmax）等指标。结果与 PKRP 组相比，PKEP 组切除前列腺腺体组织多[（52．4±15．2）g vs．（40．0±14．1）g，t ＝3．94，P ＝0．00]，术后第1天血红蛋白下降少[（9±4）g ／L vs．（17±6）g ／L，t ＝－7．36，P ＝0．00]，膀胱冲洗时间短[（1．1±0．3）d vs．（1．4±0．5）d，t ＝－3．42，P ＝0．00]，导尿管留置时间短[（3．3±0．5）d vs．（5．5±0．5）d， t ＝－20．50，P ＝0．00]。2组手术时间及术后血尿、尿失禁等并发症发生率差异无显著性（P ＞0．05）。2组术后1、3、6个月IPSS、QOL、PVR、Qmax 与术前比较均有明显改善（P ＜0．05），2组间差异无显著性（P ＞0．05）。结论经尿道 PKEP 是一种新型的适用于 BPH 的微创手术，疗效确切，安全性高。
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