Objective To investigate the expression of E-cadherin and vimentin in prostate cancer and their relationship with clinical pathological and prognosis. Method 76 patients with prostate cancer who underwent concurrent radical resection in our hospital from January 2011 to January 2013 were selected as subjects, and 76 patients with benign prostatic hyperplasia who underwent prostatectomy or prostate puncture were selected as the control group. Immunohistochemistry was used to detect the expression of E-cadherin and vimentin in prostate cancer and benign prostatic hyperplasia tissue samples, and the relationship between E-cadherin and vimentin expression and the clinicopathological features of prostate cancer was analyzed. And the association of E-cadherin and vimentin expression and the prognosis of prostate cancer was analyzed by Kaplan-Meier. Result Compared with the positive expression rate of E-cadherin in control group (81.6％), the positive expression rate of E-cadherin in prostate cancer tissues (19.7％) was signi?cantly lower (P＜0.05). And the positive expression rate of vimentin in prostate cancer tissues (73.7％) was significantly increased compared with the positive expression rate of vimentin in control group (15.7％, P＜0.05). Pathological analysis showed that the expression of E-cadherin was closely related to Gleason stage, TNM stage, prostate speci?c antigen (PSA) level and lymph node metastasis of prostate cancer (P＜0.05), and the expression of vimentin was signi?cantly correlated with Gleason stage, PSA level and lymph node metastasis of prostate cancer (P＜0.05). Kaplan-Meier survival analysis showed that the overall survival rate of E-cadherin high expression patients (93.3％) was signi?cantly higher than that of patients with low E-cadherin expression (75.4％), while the overall survival rate of vimentin high expression patients (73.2％) was signi?cantly lower than that of patients with low expression of vimentin (95.0％, P＜0.05). Conclusion Epithelial-mesenchymal transition is closely related to the invasion and metastasis of prostate cancer, and affects the prognosis of prostate cancer. It can be used as an evaluation index for prostate cancer diagnosis and prognosis.%目的 探讨上皮-间质转化相关蛋白上皮钙黏素(E-cadherin)和波形蛋白(vimentin)在前列腺癌中的表达及其与临床病理特征和预后的关系.方法 选择2011年1月至2013年1月于浙江省立同德医院确诊并行根治性切除术的76例前列腺癌患者作为研究对象,以同期于浙江省立同德医院行前列腺电切术或前列腺穿刺的76例良性前列腺增生患者为对照组.采用免疫组织化学方法检测前列腺癌及良性前列腺增生组织标本中上皮钙黏素和波形蛋白的表达情况,并分析其与前列腺癌患者临床病理特征及预后的关系.结果 前列腺癌组织中上皮钙黏素的阳性表达率(19.7％)明显低于对照组(81.6％),而波形蛋白的阳性表达率(73.7％)明显高于对照组(15.7％),差异均有显著性(P＜0.05).统计学分析显示,上皮钙黏素的表达与前列腺癌的Gleason分期、TNM分期、前列腺特异抗原(prostate speci?c antigen,PSA)水平及淋巴结转移显著相关(P＜0.05),波形蛋白的表达与前列腺癌的Gleason分期、PSA水平及淋巴结转移显著相关(P＜0.05).Kaplan-Meier生存分析显示,上皮钙黏素高表达患者的总生存率(93.3％)明显高于低表达患者(75.4％),而波形蛋白高表达患者的总生存率(73.2％)明显低于低表达患者(95.0％),差异均有显著性(P＜0.05).结论 上皮-间质转化与前列腺癌的侵袭转移及预后密切相关,可作为前列腺癌诊疗及预后的评估指标.
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