CK19和Galectin-3在甲状腺良恶性病变中的表达及鉴别诊断意义

摘要

目的：研究细胞角蛋白(CK)19和半乳糖凝集素(Galectin)-3在甲状腺良恶性病变中的表达及其在鉴别诊断中的意义。方法：应用免疫组化SP法检测85例甲状腺乳头状癌、30例结节性甲状腺肿及30例甲状腺腺瘤中CK19和Galectin-3的表达。结果：CK19和Galectin-3在乳头状癌中的表达阳性率分别为97.6%和98.8%，且大多数呈中、强阳性；在结节性甲状腺肿及甲状腺腺瘤中的阳性率分别为13.3%和23.3%及16.7%和20%，且均为弱阳性，差异有显著性(P<0.001)。结论：CK19和Galectin-3在甲状腺乳头状癌中的表达率远远高于甲状腺良性病变，两者联合检测对于甲状腺良恶性病变的诊断具有一定的临床实用价值。%Objective:To study the immunohistochemical cxpression of cytokeratin-19 and Galectin-3 in tissues from benige and malignant thyroid lesions and to evaluate its usefulness in the differential diagnoses.Methods:By Immunohistochenical SP Method,the expression of CK19 and Galectin-3 were detected in 85 cases of papillary thyroid carcinomas,30 multinodular goiters and 30 follicular adenomas. Ressults:The rate of immuno-positive staining of CK19 and Galectin-3 in papillary thyroid carcinoma were 97.6% and 98.8%,and the majority were in strongly positive;nodular goiter and thyroid adnoma positive rate are 13.3% and 23.3%,16.7% and 20%,and are weakly positive,the differce was significant(P<0.001).Conclussion:Expression of Cytokeratin-19 and Galectin-3 in papillary thyroid carcinomas were much higher than benign thyroid lesions,both combined detetion of certain clinical value for the dignosis of benign and malignant thyroid leission.