氢化泼尼松联合托烷司琼预防含顺铂化疗方案致恶心呕吐临床观察

摘要

目的：观察氢化泼尼松联合托烷司琼预防含顺铂方案的联合化疗所导致的恶心、呕吐及其他不良反应。方法：将52例含顺铂30mg/(m2·d)×3d化疗方案的恶性肿瘤患者随机分为两组进行研究，观察组26例接受氢化泼尼松联合托烷司琼治疗，对照组26例接受托烷司琼治疗。观察两组病人恶心、呕吐的控制情况及不良反应。结果：氢化泼尼松联合托烷司琼恶心和呕吐发生率均低于单用托烷司琼组差异有显著性(P<0.05)。两组不良反应发生率无明显差异(P>0.05)。结论：氢化泼尼松联合托烷司琼预防含顺铂方案的联合化疗中能有效地减轻化疗过程中恶心呕吐的程度，安全性好。%Objective:To observe the effect of hydroprednisone combined with tropisetron preventing nausea and vomiting induced by chemotherapy with cisplation.Methods:Fifty two patients with cancer undergoing chemotherapy regimens including cisplain DDP 30mg/(m2·d)×3d were divided randomly into an experimental group with 26 patients and a control group with 26 patients. The patients in the experimental group were given hydroprednisone combined with tropisetron,and the patients in the control group were given tropisetron. The situation of nausea,vomiting and adverse reactions were observed and recorded.Results:The incident rates of both nausea and vomiting in the experimental group were significantly depressed than those in the control group( P<0.05). There was no significant difference in the adverse reactions between the experimental group and the control group (P>0.05).Conclusion:Hydroprednisone combined with tropisetron was safe and effective in preventing nausea and vomiting induced by chemotherapy with cisplation.