沙美特罗替卡松粉雾化吸入治疗儿童支气管哮喘的临床研究

摘要

Objective: To investigate the salmeterol inhalation clinical curative effect and mechanism of treatment of children with bronchial asthma.Methods: 89 patients with bronchial asthma were divided into two groups: control group (fluticasone propionate aerosol inhalation, 43 cases); observation group (salmeterol and fluticasone propionate aerosol inhalation, 46 cases). After 4 weeks of treatment, the therapeutic effect was observed and the possible mechanism was analyzed.Results:After the treatment of the two groups of children, FVC, FEV1 and PEF were significantly increased, the observation group is higher than control group (P<0.05); observation group with TNF alpha, 5-HT, LC-4 and IgE levels decreased significantly, the observation group was lower than that in control group (P<0.05). In the observation group, the recurrence rate of asthma in 12 months was significantly lower than that in the control group (P<0.05).Conclusion: Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation can improve the curative effect of bronchial asthma in children.%目的：探讨沙美特罗替卡松粉雾化吸入治疗儿童支气管哮喘的临床疗效和机制。方法：89例支气管哮喘患儿分为2组：对照组（替卡松雾化吸入，43例）；观察组（沙美特罗替卡松雾化吸入，46例）。治疗4周后观察疗效并分析可能的机制。结果：两组患儿治疗后FVC、FEV1及PEF均显著升高，观察组高于对照组（P＜0.05）；观察组患儿TNF-α、5-HT、LC-4及IgE水平显著降低，观察组低于对照组（P＜0.05）。观察组患儿12个月累积哮喘复发率显著低于对照组（P＜0.05）。结论：沙美特罗替卡松粉吸入剂可提高儿童支气管哮喘的近远期疗效。