太芪培元颗粒对气阴两虚肺肾不足型HIV感染者TLR-4影响的研究

摘要

目的:观察太芪培元颗粒对气阴两虚肺肾不足型CD4 +T淋巴细胞>350个· uL-1的HIV感染者的临床疗效.方法:采用队列研究,将108例HIV感染者根据是否服用太芪培元颗粒分为暴露组及非暴露组.观察6个月,对比两组患者的CD4 +T淋巴细胞、HIV-RNA病毒载量、中医症状体征积分、Toll 样受体-4(toll like receptor-4,TLR-4)、白介素-10(IL-10)等指标的差异.结果:经过6个月的治疗,暴露组比非暴露组的中医症状体征积分、TLR-4受体指标变化差异有统计学意义(P<0.05).CD4 +T淋巴细胞、HIV-RNA病毒载量、IL-10等指标差异无统计学意义(P>0.05).结论:运用太芪培元颗粒治疗气阴两虚肺肾不足型CD4 +T淋巴细胞>350个· uL-1HIV的感染者,可以改善患者临床症状,稳定患者CD4 +T淋巴细胞计数,抑制TLR-4受体.太芪培元颗粒可能是通过机体免疫调节的过程发挥作用.%To observe the curative effect of taiqipeiyuan granules to HIV-infected patients with CD4 +T lymphocytes>350· μL -1, who were deficiency of both qi-yin and lung-kidney.Methods:One hundred and eight HIV-infected patients in this co-hort study were divided into two groups as exposure group and non-exposed group according to whether taking taiqipeiyuan gran-ules.The exposure group was taking taiqipeiyuan granules, the non-exposed group without taking taiqipeiyuan granules.After 6 months, to observe the difference between two groups of patients with CD4 +T lymphocytes,HIV-RNA viral load,TCM symptom score,TLR-4 receptor,IL-10 and other indicators.Results:After 6 months of treatment, the difference between the two groups in TCM symptom score and TLR-4 receptor were statistically significant(P<0.05).The difference between the two groups in CD4 +T cells,HIV-RNA viral load,IL-10 and so on were not statistically significant.Conclusion:Taiqipeiyuan granules can improve the clinical symptoms of HIV-infected patients with CD4 +T lymphocytes>350· uL -1, stabilize CD4 +T lymphocyte count and inhibit TLR-4 receptor.Taiqipeiyuan granules may play a role in regulating the immune process.