丹参多酚酸盐联合曲美他嗪治疗冠心病心绞痛的疗效及安全性分析

摘要

Objective:To study the clinical efficacy and safety of salvianolate combined with trimetazibine in the treatment for patients with coronary heart disease and angina pectoris,and provide the reference for the future clinical treatment of coronary heart disease and angina pectoris.Methods:The 80 patients with coronary heart disease and angina pectoris in our hospital during the period from Jan 2016 to Jan 2017 were randomized into the control group (routine treatment of nitroglycerin) and the observation group (salvianolate combined with trimetazibine),40 patients per group.The clinical efficacy of treatment,daily episodes,duration time,nitroglycerin dosage,life quality on pretherapy and post-treatment and the adverse reactions during the treatment period in two groups were compared.Results:Compared with the control group,the total effect rates of clinical symptom treatment and ECG treatment were significantly increased in the observation group,and the difference was statistically significant(P ＜ 0.05).Compared with the control group,the daily episodes,duration time,nitroglycerin dosage were obviously reduced in the observation group,and the difference was statistically significant (P ＜ 0.05).Compared with the control group,the score of life quality was significantly increased on post-treatment in the observation group,and the difference was statistically significant(P ＜ 0.05).There were no severe adverse reactions during the treatment period in two groups.Conclusion:The treatment of salvianolate combined with trimetazibine for coronary heart disease and angina pectoris can significantly increase the clinical efficacy,improve the patients' life quality with higher clinical safety.%目的:探讨丹参多酚酸盐联合曲美他嗪治疗冠心病心绞痛的临床疗效及安全性,为临床进一步治疗冠心病心绞痛提供参考.方法:选取2016年1月至2017年1月我院80例冠心病心绞痛患者,随机分为对照组(硝酸甘油等常规治疗)和观察组(丹参多酚酸盐联合曲美他嗪治疗),每组各40例,比较两组治疗的临床疗效,每天发作次数、每次发作持续时间、硝酸甘油用量以及治疗前后生活质量评分及治疗期间不良反应.结果:观察组临床症状治疗及心电图治疗的总有效率均明显增高,差异有统计学意义(P＜0.05);与对照组相比,观察组治疗后每天发作次数、每次发作持续时间、硝酸甘油用量均明显减少,差异有统计学意义(P＜0.05);与对照组相比,观察组治疗后生活质量评分升高,差异有统计学意义(P＜0.05);治疗期间两组都没有出现严重不良反应.结论:丹参多酚酸盐联合曲美他嗪治疗冠心病心绞痛,能够明显提升临床疗效,改善患者生活质量,具有治疗安全性.