To study the influence of negative electret meloxicam patch in heart function and ultrastructure of heart muscles, hepatic and nephridial tissues and explore the biological safety of the negative electret meloxicam patch. Methods: The negative electret meloxicam patch was prepared by pharmaceutical and electrical method. The related physiological indexes and tissue' s ultrastructures were studied using ALC-2000 MPA Multi-channel bio-signal analysis systemand?transmission electron microscope. Results: After the negative electret meloxicam patch was applied on Sprague Dawley (SD) rats for 8 hours, the breath wave pattern ,the heart function indexes?and the blood pressure of neck artery were similar between the two groups. There was no significant difference in pathological changes in the heart muscles, hepatic and nephridial tissues which was affected by the electret samples. Conclusions: The negative electret meloxicam patch had no negative effect on the tissues' functional indexes and typical cellular ultrastructures.Negative electret meloxicam was of good biological safety.%目的:研究负极性驻极体美洛昔康贴剂对大鼠心功能及心、肝、肾组织超微结构的影响,初步探讨负极性驻极体美洛昔康贴剂的生物安全性.方法:以美洛昔康为模型药物,用药剂学方法和栅控恒压电晕充电技术制备负极性驻极体美洛昔康贴剂,通过多通道生物信号分析系统和透射电子显微镜研究负极性驻极体美洛昔康贴剂对大鼠的呼吸、动脉血压、心电图等指标及对实验大鼠心脏、肝脏及肾脏组织超微结构的影响.结果:驻极体美洛昔康贴剂作用大鼠8h内,大鼠的呼吸波形图、颈动脉血压波形图和心电图均正常,与对照组比较差异无统计学意义.驻极体美洛昔康贴剂作用大鼠8h后,实验组和对照组实验大鼠的心肌组织、肝脏组织和肾脏组织超微组织结构均正常,未见病理改变.结论:负极性驻极体美洛昔康贴剂对实验大鼠的组织功能指标和主要细胞的超微形态均无负面影响,驻极体美洛昔康贴剂具有良好的生物安全性.
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