多种化学突触性能比较的数值模拟

摘要

目的:运用数值模拟的方法实现不同化学突触模型.方法:通过化学突触将两个Hodgkin-Huxley神经元连接构建简单的化学突触连接模型.运用Simulink软件和DSP Builder软件分别对5种化学突触数学模型建模,得到化学突触的突触电流模拟结果.采用相关系数法量化分析这几种化学突触的模拟结果.结果:不同化学突触的数学模型突触电流波形不同;数学描述和建模过程最简单的是化学突触模型1;化学突触模型1、突触模型2和突触模型3的相关系数较接近且较小,其次是化学突触模型4的相关系数,相关系数最大的是化学突触模型5,该模型实现了高精度神经元动作电位的传递.结论:突触模型5是最接近于生物学实际的化学突触;化学突触的模拟结果为后续运用硬件实现化学突触奠定了基础.%Objective To establish different chemical synapse models using numerical simulation method.Methods A simple chemical synapse connection model was constructed by connecting two Hodgkin-Huxley neurons through chemical synapses.The mathematical models of 5 kinds of chemical synapse were modeled with Simulink software and DSP Builder software,respectively,so as to simulate chemical synaptic current.The simulation results of these chemical synapses were quantitatively analyzed with correlation coefficient method.Results The synaptic current wavefomas of different mathematical synapse models were different.The chemical synapse mode l had the simplest mathematical description and modeling process.The correlation coefficients of chemical synapse model 1,synapse model 2 and synapse model 3 were closer and minimum,followed by the correlation coefficient of chemical synapse model 4.The chemical synapse model 5 with the largest correlation coefficient realized the transmission of high precision neuronal action potential.Conclusion The synapse model 5 was closest to the biological reality of chemical synapses.The simulation results of chemical synapses laid the foundation for the subsequent use of hardware to achieve the simulation of chemical synapses.