compound, pharmaceutical composition, article of manufacture, methods of treating or preventing the formation, deposition, accumulation or persistence of amyloid fibrils and synuclein fibrils, and of treating, preventing or ameliorating one or more symptoms of an amyloid disease or a synucleinopathy. in a mammal, and, compound use

摘要

COMPOSITION, PHARMACEUTICAL COMPOSITION, MANUFACTURING ARTICLE, METHODS OF TREATING OR PREVENTING THE FORMATION, DEPOSIT, ACCUMULATION OR PERSISTENCE OF SYLUCLEIN FIBRILS, AND SYRUCENUS OR PRETARIN A FEMALE OR SULUCLEIN FIBERS IN A MAMMALIAN, AND, USE OF COMPOUND. Substituted diaryl compounds of Formulas (I, II, III), wherein the variables are as defined in the claims and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them and their use in the treatment of amyloid diseases, including amyloidosis A 225 , as observed in Alzheimer's disease, IAPP amyloidosis, as seen in type 2 diabetes and synucleinopathies, as seen in Parkinson's disease, and the manufacture of medicaments for such treatment is provided.