目的 从心肌灌注模型角度出发,对13N-NH3·H2O动态心肌灌注显像的资料进行定量分析,并对不同模型进行评价.方法 对4名正常体检者行13N-NHa·H2O动态心肌灌注显像,用Carimas软件分别通过Duke模型和Michigan模型进行定量分析,比较心肌血流量(MBF)、心肌氨水摄取率(k1)、心肌氨水洗脱率(kz)等定量指标.结果 Duke模型测得心肌的整体MBF、k1均为(0.770±0.332)ml/(g·min),k2为(0.219±0.253)min-1；Michigan模型测得心肌的整体MBF为(0.825±0.401)ml/(g·min)、k1为(0.704±0.256)ml/(g·min)、k1/k2为(3.134±0.715)ml/g.两模型测得的结果线性相关且均符合相关文献的报道,但Duke模型测得心尖部位的MBF和k1较Michigan模型均偏大.结论 使用PET/CT 13N-NH3·H2O动态心肌灌注显像定量分析可根据需求选择合适的模型.%Objective To apply 13N-NH3 · H2O dynamic myocardial perfusion imaging based on myocardial perfusion models, and to quantitatively analyze the normal imaging data and then evaluate the models. Methods 13 N-NH3 · H2O was used as the imaging agent for PET/CT perfusion imaging. Four normal subjects were analyzed quantitatively by Duke model and Michigan model using Carimas software, and myocardial blood flow (MBF), myocardial ammonia uptake rate (k1), myocardial ammonia washout rate (k2) and other quantitative indicators were compared. Results In Duke model global MBF and k1 was both (0. 770 ±0. 332) ml/(g · min),.k2 was (0. 219 ± 0. 253)min-1. In Michigan model, global MBF was (0. 825±0. 401)ml/(g · min) , k1 was (0. 704±0. 256)ml/(g · min) , k1/k2 was( 3. 134 + 0. 715)ml/g. Though values of MBF and k1 in apex of Duke model were larger than those of Michigan model, and the results assessed by two models were linearly correlative and consistent with literature reports. Conclusion For quantitative analysis of 13N-NH3 · H2O dynamic myocardial perfusion imaging with PET/CT, it is necessary to choose proper model.
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