目的 探讨乙醇对猫脑创伤性脑损伤(TBI)后脑水肿的影响.方法 将14只健康成年猫分为创伤性脑损伤组(T组)和急性酒精中毒合并TBI组(ET组),分别在模型制作后的3、6、24、48 h进行MR扫描,通过计算FLAIR序列最大层面异常高信号的面积,评估脑损伤后脑水肿的变化并进行比较.结果 ET组和T组异常高信号的面积均随时间推移(3、6 h)而增大,至24 h达到高峰后开始下降,且ET组异常信号的面积高于T组(t=2.70,P=0.01).结论 乙醇通过影响创伤后的脑水肿而加重猫TBI的发展,这可能是急性酒精中毒合并TBI预后不良的原因.%Objective To investigate the impact of prior ethanol consumption on brain edema after traumatic brain injury of cat models. Methods Fourteen healthy cats were randomly divided into traumatic brain injury (TBI) group (T group) and acute alcoholic intoxication associated with TBI group (ET group). MR examination was done at 3, 6, 24, 48 hours after the modeling, respectively. The biggest areas of abnormal signal on FLAIR were calculated to evaluate and compare the development of brain edema after traumatic brain injury. Results The biggest areas of hyper signal on FLAIR of the two groups increased with time going, reached peak at 24 hours and then decreased. The areas of hyper signal on FLAIR in ET group were greater than in T group (t = 2. 70, P = 0. 01). Conclusion Alcohol consumption aggravates TBI through its impact on traumatic brain edema, and it may explain why acute alcoholic intoxication associated with poor prognosis of TBI.
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