脑胶质瘤IDH基因突变与定量多模态MRI研究进展

摘要

异柠檬酸脱氢酶(IDH)基因突变与脑胶质瘤的发生、预后及对治疗的反应有密切关系.由于IDH是细胞能量代谢重要的限速酶,IDH基因突变改变了IDH与底物的亲和力和代谢方向,使肿瘤代谢和微观结构发生改变.定量多模态MRI能够获得多种与微观结构、功能和代谢产物相关的影像学生物标记,有望通过检测影像学生物标记在体评价IDH基因突变引起的胶质瘤代谢和微结构改变.本文对近年来有关脑胶质瘤定量多模态MRI特征与IDH基因突变关系的研究进展进行综述.%The mutation of isocitrate dehydrogenase (IDH) gene is associated with gliomagenesis.It has also significant positive effects on survival and chemosensitivity in comparison with IDH wild-type glioma.Being an important energetic metabolism enzyme,mutation of IDH results in changes of microstructures and metabolism.Quantitative multimodality MR imaging has ability to obtain imaging biomarkers about microstructural,physiologic and functional information,which demonstrates the promises to assess IDH gene status in vivo.The progresses of association between quantitative multimodality MRI features and IDH genesmutations in glioma were reviewed in this paper.