7.0T静息态fMRI分析恒河猴脑默认网络

摘要

目的 分析健康恒河猴大脑的默认网络(DMN)结构.方法 采用7.0T fMRI获得麻醉状态下健康恒河猴的静息态数据;以DPARSF软件包对猴脑静息态功能像进行预处理,将其配准到恒河猴标准模板112SM-RL T1;之后利用GIFT软件包对预处理后的功能像数据进行组独立成分分析.结果 本文方法可较准确地对猴脑静息态数据进行预处理,并获得静息态脑网络功能连接图;其中DMN包括位于中线区的后扣带回、前扣带回、内侧顶叶皮质、后压部皮质以及大脑左右半球较为对称的腹侧壁内区域、背侧颞上沟回、颞区、弓状沟回及部分视觉区域等脑区.结论 借助7.0T fMRI,本文证实恒河猴默认网络与人类默认网络在结构上具有相似性,此类模型可辅助进行药理性实验研究以及神经认知类研究.%Objective To investigate default mode networks (DMN) in healthy rhesus monkey brain.Methods Under anesthesia,two healthy rhesus macaques underwent resting state fMRI at a 7.0T MR scanner.The functional images were firstly normalized to the standard rhesus monkey template 112SM-RL-T1,and the GIFT software was aplied to conduct group-level independent component analysis on all preprocessed functional images.Results The functional connectivity maps of the resting-state networks of rhesus macaques were obtained using this method.DMN bilaterally included posterior cingulate cortex,anterior cingulate cortex,medial parietal cortex,retrosplenial cortex,arcuate sulcus,ventral intraparietal area,temporoparietal area,superior temporal sulcus dorsal bank and a portion of visual cortex.Conclusion With the help of cutting-edge 7.0T fMRI technology,It was demonstrated that DMN of rhesus macaque brain highly resembled the ones in human,which could support the notion that non-primates are useful models for neuropharmacological and neurocognitive studies.