The Identification of Default Mode Network in Rhesus Macaque Using Resting-State fMRI

摘要

To investigate Default Mode Network (DMN) in healthy rhesus monkey brain using Resting-State functional Magnetic Resonance Imaging (RS-fMRI). Under anesthesia, two healthy rhesus macaques underwent RS-fMRI at 7.0T using equal imaging parameters. The functional images were first spatially normalized to the standard rhesus monkey template 112SM-RL-T1, and the GIFT software was utilized to carry out group-level Independent Component Analysis (group-ICA) on all preprocessed functional images. The results demonstrated that our method can obtain functional connectivity maps of the resting-state networks. Among them, the DMN bilaterally includes posterior cingulate cortex, anterior cingulate cortex, medial parietal cortex, retrosplenial cortex, arcuate sulcus, ventral intraparietal area, temporo-parietal area, superior temporal sulcus dorsal bank and a portion of visual cortex. With the help of cutting-edge 7.0T fMRI technology, our result confirms that the DMN of the monkey brain highly resembles the ones in human; it supports the notion that non-primates are useful models for neuropharmacological and neurocognitive studies.