子宫内膜区域不均质回声对体外受精/卵胞浆内单精子显微注射临床结局的影响

摘要

Objective To observe the impact of heterogeneous echo in endometrial region on pregnancy rate after fertilization in vitro/intracytoplasmic sperm injection (IVF/ICSI).Methods Totally 334 patients who underwent IVF/ICSI therapy were enrolled.According to results of B-mode ultrasound in the course of promoting drainage,the patients were divided into heterogeneous echo group (n=88) and normal echo group (n=246).Pregnancy conditions were compared between the two groups.Results Heterogeneous echo group showed significant lower pregnant rate than normal echo group (68.18％ [60/88] vs 78.86 ％ [194/246],P=0.01),while the ectopic pregnancy rate of heterogeneous echo group was higher than that of the normal echo group (5.00％ [3/60] vs 1.03％ [2/194],P=0.01).Pregnancy rate of endometrial thickness patients were higher than that of patients without endometrial thickness in two groups (all P＜0.05).Conclusion Pregnant rate reduced and ectopic pregnancy rate increased in infertility patients with endometrial heterogeneous echo,while higher 10 mm endometrial thickness could contribute to increase pregnant rate.%目的 评估体外受精/卵胞浆内单精子显微注射(IVF/ICSI)治疗过程中子宫内膜区域不均质回声对妊娠概率的影响.方法 收集接受IVF/ICSI治疗患者334例,根据IVF/ICSI促排卵过程中B超结果,分为不均质回声组(n=88)和正常回声组(n-246),比较两组患者妊娠情况.结果 正常回声组妊娠概率高于不均质回声组[78.86％(194/246) vs68.18％(60/88),P=0.01],正常回声组异位妊娠率低于不均质回声组[1.03％(2/194) vs 5.00％(3/60),P=0.01].不均质回声组和正常回声组内膜增厚患者妊娠率高于无增厚患者(P均＜0.05).结论 不孕症患者合并内膜区域不均质回声时,妊娠成功率明显降低,异位妊娠率明显增高;但子宫内膜厚度大于10 mm依然有利于妊娠.