维生素D受体基因多态性与维吾尔族老年轻度认知功能障碍的相关性

摘要

Objective To assess the association of vitamin D receptor gene(VDR) Apa Ⅰ , Bsm Ⅰ genotypes and allele frequencies and mild cognitive impairment(MCI) among elderly ethnic Uygurs from Xinjiang, China.Methods The polymorphisms of the VDR genotypes(Apa Ⅰ and Bsm Ⅰ) were analyzed by the SNaPshot method in 124 MCI patients and 124 controls.Results Factors which can increase the risk for MCI have included the A allele of the Apa Ⅰ polymorphism [OR=1.62, 95％CI(1.13-2.31)] and the AAgenotype[OR=3.49, 95％ CI(1.57 7.74)], the T allele of the Bsm Ⅰ polymorphism [OR=1.94, 95 ％ CI(1.24-3.05)], higher triglyceride and systolic blood pressure levels.Conclusion Polymorphisms of the VDR gene including the A allele and AA genotype of Apa Ⅰ , and the T allele of Bsm Ⅰ are probably associated with MCI among elderly ethnic Uygurs, and so are higher levels of triglyceride and systolic blood pressure.%目的 探讨维生素D受体(vitamin D receptor,VDR)基因ApaⅠ、Bsm Ⅰ位点不同基因型以及等位基因频率的分布与维吾尔族老年轻度认知功能障碍(mild cognitive impairment,MCI)的相关性.方法 应用SNaPshot方法检测124例MCI患者和124名维吾尔族对照VDR基因Apa Ⅰ、Bsm Ⅰ位点的基因多态性分布.结果 可增加MCI的患病风险的因素包括VDR基因ApaⅠ位点等位基因A/[OR=1.62,95％CI(1.13～2.31),P＜0.05]及AA基因型[OR=3.485,95％CI(1.57～7.74),P＜0.05]、BsmⅠ位点的T等位基因[OR=1.94,95％CI(1.24～3.05),P＜0.05]、甘油三酯水平[OR=l.33,95％CI(1.13～1.58),P＜0.05]以及收缩压增高[OR=1.02,95％CI(1.01～1.03),P＜0.05]等.结论 VDR基因ApaⅠ位点的AA基因型、等位基因A和Bsm Ⅰ位点的T等位基因可能与新疆维吾尔族老年MCI的发病相关.甘油三酯水平增高、收缩压增高可能是维吾尔族老年MCI的独立危险因素之一.