Relationship between vitamin D receptor gene polymorphism and mild cognitive impairment in elderly Uygur people

摘要

To explore the relationship between vitamin D receptor gene (ApaI, BsmI) genotypes and allele frequency and mild cognitive impairment in Xinjiang Uygur population. The polymorphisms of the VDR genotypes (ApaI and BsmI) were analyzed by Snapshot method in 124 MCI patients and 124 controls. A allele of ApaI gene increased the risk of MCI [emOR/em = 1.62, 95% CI (1.13-2.31)]; AA genotype increased the risk of MCI [emOR/em = 3.49, 95% CI (1.57-7.74)]. T allele of BsmI gene increased the risk of MCI [emOR/em = 1.94, 95% CI (1.24-3.05)]. The risk of MCI increased accompanied with higher TG and SBP level. VDR (ApaI) AA genotype, a allele and VDR (BsmI) T allele probably associated with elderly MCI patients in Uygur ethnicity, higher level of TG and SBP were risk factors to elderly people with MCI among Uygurs.