目的：采用结构性磁共振成像技术，对正常人群大脑皮层言语相关区域的结构性不对称进行研究。材料与方法对60例健康志愿者行高分辨三维T1结构性MRI扫描，选择以下5个脑区作为感兴趣区(ROI)：额下回岛盖部、额下回三角部、颞横回、颞平面及岛叶，应用Freesurfer软件进行表面的重建及皮层厚度、皮层表面面积和皮层体积等解剖学结构的测量。比较每个ROI的两侧解剖学测量值和偏侧化指数(LI)，并进行相关分析。结果颞横回皮层厚度呈右侧化不对称，岛叶皮层厚度呈左侧化不对称，额下回岛盖部、颞横回、颞平面及岛叶皮层表面面积与皮层体积均呈左侧化不对称；所有ROI的皮层厚度与皮层表面面积均无明显相关；皮层厚度的不对称与皮层体积的不对称无明显相关，皮层表面面积的不对称与皮层体积的不对称均呈明显的正相关。结论言语相关脑区皮层结构主要表现为左侧化的不对称，皮层厚度和皮层表面面积是相互独立的，皮层体积的不对称主要由皮层表面面积的不对称决定。%AbstractObjective: This investigation analyzes the structural asymmetry in the human language-related cortex by means of structural magnetic resonance imaging. Materials and Methods:High-resolution three-dimensional T1 structural MRI scans were obtained from 60 participants. 5 regions of interest (ROIs) were selected: pars opercularis (POp), pars triangularis (PTr), anterior transverse temporal gyrus /Heschlʼs gyrus (HG), planum temporale (PT) and insula. A Freesurfer post processing pipeline was employed to perform surface reconstruction and measurements of cortical thickness (CT), cortical surface area (CSA) and cortical volume (CV). Differences between two sides of the anatomical measurements and laterality index (LI) of every ROI were analyzed. The correlation analysis was performed for the three measurements and their LI.Results:A right asymmetry in the HG and a leftward asymmetry in the insula was observed for CT. The POp, HG, PT, and insula were signiifcantly leftward asymmetry for CV and CSA. No signiifcant correlations between CT and CSA were found. The correlation between thickness asymmetry and volume asymmetry was not significant. Significant positive correlation exists between CSA asymmetry and CV asymmetry for all ROIs.Conclusions:The cortical architecture of language-related areas mainly showed a leftward asymmetry. CT and CSA were independent traits, and CV asymmetry was determined mostly by CSA asymmetry.
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