肿瘤细胞代谢与肿瘤转移相互关系的研究进展

摘要

Intracellular nutrients and the rate of energy lfowing in tumor cells are otfen higher than that in normal cells due to the prolonged stress of tumor-speciifc microenvironment. In this context, the metabolism of tumor cells provides the fuel of bio-synthesis and energy required for tumor metastasis. Consistent with this, the abnormal metabolism such as extremely active glucose metabolism and excessive accumulating of fatty acid is also discovered in metastatic tumors. Previous Studies have conifrmed that the regulation of tumor metabolism can affect the tumor metastasis, and some of these have been successfully applied in clinical effective, positive way. hTus, targeting metabolism of tumor cells might be an effectively positive way to prevent the metastasis of tumor. So, our review is focused on the research development of the relationship between tu-mor metabolism and metastasis as well as the underlying mechanism.%肿瘤细胞长期处于应激的微环境中，细胞内营养物质及能量的流通速率往往高于正常细胞，肿瘤细胞代谢以此为肿瘤转移提供生物合成原料和能量。在转移性肿瘤中也发现糖代谢异常活跃、脂肪酸过度累积等异于正常细胞的代谢反应。已有研究证实对肿瘤细胞代谢进行调节可影响肿瘤转移，部分成果已应用于临床治疗，靶向肿瘤细胞代谢是抗肿瘤转移的一个积极有效的方向。本文对目前肿瘤细胞代谢与肿瘤转移相互关系和调节机制的研究进展进行综述。