MicroRNA与肺癌顺铂耐药相关性研究进展

摘要

MicroRNAs (miRNAs) are a class of small, about 22 nucleotides endogenous noncoding RNAs that negatively regulate their target genes’ expression through post-transcriptional suppression. MicroRNA has a broad effect on tumorigenesis and tumor biological processes, including tumor development, differentiation, metastasis and chemoresistance. Chemoresistance represents a major obstacle in effective clinical treatment of tumors, how to conquer the chemoresistance in tumor arouses people’s interst. A growing number of studies have proved that microRNAs play a crucial role in tumor che-moresistance. hTis view will discuss the the progress research between microRNA and tumor therapy, especially the cisplatin chemotherapy in tumor.%微小RNA（microRNA, miRNA）是一类长约22 nt的非编码小分子RNA，在转录后水平上负性调节靶基因的活性。微小RNA在肿瘤的发生、发展中发挥着广泛的作用，包括肿瘤的进展、分化、转移和耐药等。化疗药物的耐药是临床肿瘤治疗的难题，如何克服肿瘤细胞的顺铂耐药性引起人们的广泛兴趣。越来越多的研究证明微小RNA在影响肿瘤耐药中发挥着重要的作用。本文将对微小RNA与肿瘤治疗尤其是顺铂治疗的研究进展作一综述。