近红外波辅助治疗慢性乙型肝炎及肝硬化临床疗效评价

摘要

Objective To evaluate the clinical effect of near-infrared wave in the assisted treatment of chronic hepatitis B and associated cirrhosis. Methods Total of 54 cases with chronic hepatitis B were randomly divided into two groups, 27 cases in each group;12 patients with cirrhosis were randomly divided into two groups, 6 cases in each group. Patients in two groups were given the antiviral and hepatoprotective treatment, and patients in treatment group were also applied with near-infrared wave at the same time, the efifcacy of the two groups were analyzed. Results For chronic hepatitis B patients, the periods of hospitalization and symptom improvement between the treatment group and control group were signiifcantly different (P=0.041, 0.015) but there is no signiifcant difference on period of ALT recovery (P=0.082);alos with signiifcant differences in white blood cells count, hemoglobin concentration, HBsAg titer (P=0.560, 0.471, 0.520);and the platelet was signiifcantly higher after in treatment group (P=0.001). For cirrhosis patients, the group treated with near-infrared wave was compared with the control group, there were signiifcant differences in the periods of hospitalization and ALT recovery (P=0.021, 0.023);also with significant differences in white blood cells count, hemoglobin concentration, HBsAg titer (P=0.721, 0.562, 0.895);and the platelet was signiifcantly higher in treatment group (P=0.012), but there is no signiifcant difference on period of symptom improvement (P=0.075). Conclusions There is a certain clinical effect for near-infrared wave in the treatment of patients with hepatitis B and cirrhosis, which can be taken as a mean of assisted therapy.%目的探讨近红外波辅助治疗慢性乙型肝炎（CHB）及乙型肝炎后肝硬化的临床疗效。方法选择CHB患者54例，随机分为治疗组与对照组（各27例）；肝硬化患者12例，随机分为治疗组与对照组（各6例）。对照组应用抗病毒药物和保肝药物治疗，治疗组在对照组治疗基础上使用近红外波治疗，比较两组治疗效果。结果两组CHB患者实际住院天数，症状改善时间差异均有统计学意义（P=0.041、0.015）；治疗后丙氨酸氨基转移酶（ALT）复常差异无统计学意义（P =0.082）；治疗后白细胞（WBC）、血红蛋白（HB）、乙型肝炎病毒表面抗原（HBsAg）比较，差异均无统计学意义（P =0.560、0.471、0.520）。治疗组CHB患者血小板（PLT）显著高于对照组（P =0.001）。乙型肝炎后肝硬化患者治疗组实际住院天数、ALT与对照组比较，差异均有统计学意义（P =0.021、0.023）；治疗后症状改善时间与对照组比较，差异无统计学意义（P=0.075）；治疗后WBC、HB、HBsAg比较，差异均无统计学意义（P =0.721、0.562、0.895）。治疗组肝硬化患者治疗后PLT数量与对照组比较，差异有统计学意义（P =0.012）。结论近红外波辅助治疗乙型肝炎及肝硬化患者具有一定的临床疗效，可作为乙型肝炎及肝硬化患者的辅助治疗手段。