慢性HBV感染免疫耐受期T淋巴细胞研究进展

摘要

In the natural history of chronic hepatitis B virus (HBV) infection, the immune tolerance (IT) phase represents the classical early phase of infection, which plays a decisive role in the monitoring and treatment. In order to explore the mechanism of IT and ifnd effective treatment methods, a large numbers of studies have been published based on the connection between the virus and the host. The immunodeifciency of host may act as a signiifcant mechanism of IT, that is why T cells involved in the immune response plays an important role in CHB infection of IT.%在慢性HBV感染自然史中，免疫耐受期是疾病发展的早期阶段，对疾病的监测及治疗起决定性作用。为探索免疫耐受机制，寻找有效的治疗方法，以HBV为基点，辐射至宿主的大量列队研究不断地涌出。宿主的免疫紊乱可能是免疫耐受的主要原因，T细胞参与的免疫反应在慢性HBV感染的免疫耐受期起着重要的作用。