脂蛋白相关磷脂酶A2水解脂蛋白(a)连接的氧化磷脂促进动脉粥样硬化发生发展作用机制的研究进展

摘要

脂蛋白(a)[Lp(a)]是动脉粥样硬化(AS)形成与进展的高危因素,血浆中高浓度的Lp(a)已成为公认的冠心病预测因子.研究表明,与Lp(a)相连的氧化磷脂(OxPL)成分可能是其致AS的关键因素,而与Lp(a)相连的另一个组分——脂蛋白相关磷脂酶A2(Lp-PLA2)可水解OxPL,其水解产物溶血磷脂酰胆碱(Lyso-PC)和游离氧化脂肪酸(oxFFA)是促进AS发生发展的重要炎症因子.脂蛋白相关磷脂酶A2水解脂蛋白(a)连接的氧化磷脂可产生炎性因子,促进动脉粥样硬化的发生发展.OxPL和Lp-PLA2可作为心血管疾病(CVD)新靶标,具有潜在预测指标的临床应用价值.%Lipoprotein ( a ) [ Lp ( a ) ] is considered a causal risk factor for the formation and development of atherosclerosis ( AS).High plasma levels of Lp ( a) is recognized as a predictor of coronary heart disease. However, the pathogenic mechanisms of Lp ( a ) are still unknown. Recent studies demonstrated that a key role in the proatherogenic effects of Lp ( a ) may be linked to its oxidized phospholipids ( OxPL) content.Lipoprotein-associated phospholipase A 2 ( Lp-PLA2 ) is another important factor in Lp( a) functionality.OxPL are hydrolyzed by Lp-PLA2 into lysophosphatidylcholine ( lyso-PC) and oxidized free fatty acid(OxFFA), which are important inflammatory factors on promoting the occurrence and development of AS.The present review article describes Lp-PLA2 hydrolyzing OxPL associated with Lp (a). The process induces inflammatory factors , which promote development of AS .OxPL and Lp-PLA2 can be used as new targets of cardiovascular diseases , which have clinical application value to predict potential cardiovascular diseases .