生物样本库建立现况及进展

摘要

Biobank is a biorepository which organized for collecting and storing human biospecimen as well as associated information for research uses.Biobank is the fundamental platform which translates the basic research result into clinical practice.It also plays an important role in disease diagnosis,new drug development,disease-related genetic research and epidemiological studies.The rise of translational medicine promotes the construction and development of the biobank.This review highlights the necessity to establish biobank,and focuses on the recent advances of the modem type of biobank,quality control of biospecimens,construction of biobank,best practices and guideline applied for biobank.This review also provides information for improvement of biobank.%生物库的建立是为了1个或多个研究目的,有组织地收集并储存人体样本及其相关信息的机构.生物库可作为基础研究成果向临床应用转化的基础平台,在疾病诊断、新药研发、疾病相关基因研究及流行病学研究中均有重要作用.转化医学的兴起促进了生物样本库的建立及发展.我们主要阐述生物样本库建立的必要性、现代生物库类型、样本质量控制、生物库构建及操作指南的现况及研究进展,以为生物库的完善提供参考.