缺血性脑卒中血液生物标志物的检测及临床应用

摘要

缺血性脑卒中的早期诊断和及时治疗是减轻脑损伤、改善预后的重要因素.静脉注射重组组织性纤溶酶激活剂进行溶栓治疗是唯一证实有效的途径,但是狭窄的时间窗限制了它的使用.一种快速有效的血液检测,辅助影像学如CT等对缺血性脑卒中进行早期诊断,将有助于临床工作者迅速做出有效治疗和干预,对疾病的预后有着重要影响.本文总结已报道的蛋白质和RNA标志物,并对其作为急性缺血性脑卒中的临床应用做出分析.%Early diagnosis and timely treatment are two critical factors in reducing the cerebral damage and improving prognosis for ischemic stroke patients.The only proved effective way is to intravenously administer recombinant tissue plasminogen activator for thrombolytic therapy.However,the narrow time window restricts its application.One rapid and effective blood test,or auxiliary examinations such as computer tomography which may aid early diagnosis of ischemic stroke would contribute to treatment and intervention promptly,then take a pivotal role for the disease prognosis.Herein,the reported proteins and RNA markers are summarized and analysed in clinical application of acute ischemic stroke likewise.