浙江省中医院健康儿童血清骨碱性磷酸酶水平的研究

摘要

目的 对浙江省中医院健康儿童的血清骨碱性磷酸酶水平进行研究.方法 选取2013年8月至2014年4月在浙江省中医院下沙院区儿科体检的990名0～16岁健康儿童,应用贝克曼库尔特UniCel Dx I 800免疫分析系统测定血清骨碱性磷酸酶水平.使用Z检验验证年龄和性别分组后,计算血清骨碱性磷酸酶的第2.5和97.5百分位值.结果 正常儿童的血清骨碱性磷酸酶水平为(双侧95％区间):婴儿期(0～1岁):37 ～ 300 μg/L;幼儿期-学龄期(＞1～9岁):40 ～ 196 μg/L;青春期(＞9 ～16岁):25 ～ 284μg/L(男性),30 ～ 199 μg/L(女性).男性儿童血清骨碱性磷酸酶的水平与身高有极弱的正相关性(r =0.143,P=0.013);女性儿童血清骨碱性磷酸酶的水平与身高无显著相关性(r=0.157,P=0.83).结论 初步建立了本院实验室的健康儿童的血清骨碱性磷酸酶水平,不同性别和年龄段的儿童的骨碱性磷酸酶水平不同.%Objective To study the levels of bone alkaline phosphate (BALP) in healthy children in the specific hospital.Methods Totally 990 healthy children from 0-16 years old were selected,all of whom received physical examination in the Xiasha branch of Zhejiang Provincial Hospital of TCM during August 2013 to April 2014.Serum was collected and tested for BALP levels with a Beckman Coulter Immunoassay System UniCel DxI 800.Z-test was used to verify age and gender grouping,after which the 2.5th and 97.5th percentile values of serum BALP levels were calculated.Results The levels of serum BALP(bilateral 95％ range) in healthy children were as follows:trottie stage (0-1 years old):37-300μg/L;infancy to school stage (＞ 1-9 years old):40-196 μg/L;puberty stage (＞9-16 year-old):25-284 μg/L (male),30-199 μg/L (female).The serum BALP levels of male children showed a weak correlation with height,while the correlation for female children was not significant.Conclusions The levels of BALP in healthy children of the specific hospital and area were established.Serum BALP levels in children varied with age and sex.